complex cases leaving you with more questions than answers?
Wondering when Lyme and co-infections might be part of the picture?
where most practitioners get stuck
Let’s be honest..
Lyme disease is talked about everywhere but the training is often fragmented, overly simplified, or focused only on protocols.
Practitioners are constantly absorbing information from social media, webinars, podcasts, and practitioner groups… but still feel uncertain about how to confidently apply it in real clinical practice.
You may suspect Lyme is playing a role in many of your most complex cases yet feel unsure how to move from suspicion to structured strategy.
You might be asking yourself:
• When should I actually suspect Lyme or co-infections in a case?
• Which symptoms point toward Bartonella vs Babesia vs other co-infections?
• How reliable are Lyme labs — and how should I interpret conflicting results?
• What do I do when a client clearly has symptoms but their testing is inconclusive?
• How do I distinguish Lyme from mold illness, toxins, or other chronic drivers?
• What systems are most impacted by chronic infection — and how should I support them?
• When should treatment begin — and when does the body need stabilization first?
• How do I support clients through Herxheimer reactions or treatment intolerance?
• How do I build protocols that go beyond just antimicrobial supplements?
• What if the nervous system, immune system, and mitochondria are all destabilized at once?
• How do I approach Lyme in sensitive or highly reactive clients?
• How do I support long-term recovery after infection?
The truth is, most practitioners aren’t missing intelligence or dedication.
They’re missing a structured clinical framework.
Lyme and co-infections are rarely just about the pathogen itself. They create systemic disruption across multiple physiological systems — immune regulation, neurological function, mitochondria, hormones, and inflammatory pathways.
Without understanding how those systems interact, it’s easy to feel stuck.
The Lyme Mastery Method was designed to change that.
Instead of memorizing endless protocols, you’ll learn how to recognize patterns, understand the systemic impact of Lyme and co-infections, and develop a more strategic clinical approach to these complex cases.
INTRODUCING…
the lyme mastery method
Where we help you understand the complexity of Lyme and co-infections and apply real-world clinical strategies with confidence to elevate your clinical decision-making
Inside our certification program you’ll learn how to:
Recognize the clinical patterns of Lyme and co-infections including when symptoms point toward Bartonella, Babesia, Ehrlichia, or other infections
Interpret Lyme testing with greater confidence and understand the limitations of common lab approaches
Connect symptoms, case history, and lab findings to determine when infection may be contributing to chronic illness
Differentiate Lyme from other complex drivers such as mold illness, toxin exposure, immune dysregulation, and mitochondrial dysfunction
Understand the multi-system impact of Lyme including immune disruption, neuroinflammation, autonomic dysfunction, endocrine shifts, and mitochondrial stress
Support the most affected systems first so clients are more resilient before antimicrobial strategies begin
Navigate treatment reactions and Herxheimer responses without overwhelming sensitive or highly reactive clients
Build strategic recovery protocols that go beyond antimicrobials to support immune regulation, nervous system stability, and long-term resilience
we cover the gaps other trainings miss
Most Lyme education focuses on the infection itself. Ours goes deeper.
We dive into the real-world complexity practitioners face when Lyme and co-infections enter the picture—how to recognize clinical patterns, interpret imperfect testing, stabilize sensitive clients, and support the systems that infections disrupt.
This isn’t just theory. It’s clinical strategy, application, and real-world decision making.
Inside the Lyme Mastery Method, we focus on the areas where many trainings fall short:
Clinical pattern recognition so you can identify when symptoms point toward Lyme or specific co-infections
Lyme lab interpretation to help you understand the strengths and limitations of common testing methods and what to do when results are inconclusive
Differential thinking to distinguish Lyme from mold illness, toxin exposure, immune dysregulation, or mitochondrial dysfunction
Systems-based recovery strategies that address immune imbalance, neuroinflammation, autonomic dysfunction, and mitochondrial stress
Protocol sequencing to know when to stabilize first and when antimicrobial strategies are appropriate
Supporting sensitive or reactive clients who struggle with treatment reactions or Herxheimer responses
Clinical communication for a how to guide clients through complex diagnoses and long recovery timelines without creating fear or overwhelm
Understanding the role of nervous system dysfunction, limbic sensitization, and immune dysregulation that often complicate chronic infection recovery
Support from our clinical training team so you can apply what you’re learning and troubleshoot real cases as you go
Modeled case examples and practical frameworks to help you translate theory into confident clinical decisions
a look inside
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We begin by stepping back and examining the bigger picture of Lyme disease—how it came to be defined, why the medical community remains divided, and why so many patients fall through the cracks of conventional diagnosis and care.
In this foundational module, you’ll gain a deeper understanding of the political, clinical, and biological factors that shape how Lyme disease is recognized and treated today. We’ll explore why standard testing often fails to capture the full picture and why chronic infection challenges the traditional “one pathogen, one disease” model of medicine.
This module lays the groundwork for the entire program by helping you understand why Lyme cannot be approached through pathogen-focused thinking alone—and why host resilience, terrain, and systemic health must be part of the conversation.
You'll learn:The history of Lyme disease and how diagnostic criteria and treatment guidelines were shaped
• The divide between conventional infectious disease models and clinicians who recognize persistent infection
• Why Lyme often becomes a political and clinical battlefield rather than a straightforward diagnosis
• The biological survival strategies of Borrelia, including pleomorphism, immune evasion, intracellular persistence, and biofilm formation
• Why conventional testing models frequently produce false negatives or incomplete information
• How antibody-based testing works—and why immune dysfunction can make results unreliable
• How to interpret Lyme testing more thoughtfully by understanding antibody bands and pattern recognition
• Why antibiotics alone often fail to resolve chronic Lyme cases
• The difference between reducing microbial load and restoring host resilience
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In this module, we dive deeper into the biology of Lyme disease and the complex web of co-infections that often accompany it.
Borrelia burgdorferi is not a simple bacterium. It is highly adaptive, capable of shifting forms, evading the immune system, forming biofilms, and invading tissues throughout the body. Understanding how this organism survives—and how it disrupts multiple body systems—is essential for recognizing chronic infection patterns in practice.
We’ll also explore the broader infectious landscape that often accompanies Lyme. Ticks rarely transmit a single pathogen, and treatment-resistant cases frequently involve overlooked co-infections such as Babesia, Bartonella, Ehrlichia, Mycoplasma, viral reactivation, and parasitic burden.
This module helps practitioners move beyond simple pathogen lists and develop the clinical pattern recognition needed to identify infection-driven illness—even when testing is incomplete or inconclusive.
You’ll learn:
The survival strategies of Borrelia burgdorferi, including immune evasion, pleomorphism, intracellular hiding, and biofilm formation
• How Borrelia targets specific tissues such as the nervous system, connective tissue, vascular system, and immune pathways
• The concept of autoimmune mimicry and how chronic infection can trigger autoimmune-like symptoms
• How Lyme presents through distinct symptom clusters across neurological, psychiatric, musculoskeletal, cardiac, endocrine, and dermatologic systems
• Why pediatric Lyme often appears as behavioral or psychiatric changes rather than classic infectious symptoms
• The most common Lyme co-infections and the symptom patterns that help differentiate them
• Key clinical clues that point toward organisms such as Babesia, Bartonella, Ehrlichia, Mycoplasma, and others
• Why Lyme cases frequently involve viral reactivation and parasitic terrain shifts
• The strengths and limitations of common Lyme testing methods
• When laboratory testing can provide useful data—and when clinical diagnosis becomes more reliable
• How to interpret Western Blot patterns, band specificity, indeterminate results, and cross-reactivity
• When retesting is appropriate—and when chasing labs may only create confusion
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By the time practitioners begin working with complex Lyme cases, many discover that the infection itself is only one part of the problem.
Chronic Lyme is rarely just microbial persistence—it is a state of terrain collapse, where infection, toxic burden, immune dysregulation, mitochondrial stress, and nervous system instability all interact to perpetuate illness.
In this module, we introduce the systems-based clinical framework used throughout the program. Rather than focusing on aggressive antimicrobial treatment alone, you’ll learn how to sequence care in a way that stabilizes the body, reduces toxic burden, and supports resilience before strategically addressing infection.
This framework helps practitioners avoid one of the most common pitfalls in Lyme care: overwhelming the patient with antimicrobial strategies before the body has the capacity to tolerate them.
You’ll learn:
The four-phase clinical framework for working with complex Lyme cases: terrain stabilization, environmental load reduction, microbial strategy, and long-term recovery
• Why stabilizing the terrain must come before antimicrobial intervention in many patients
• How nervous system dysregulation, sleep disruption, and metabolic instability can amplify inflammation and treatment reactions
• The importance of drainage pathways and detox capacity when microbial die-off occurs
• How mineral depletion, bile flow impairment, and mast cell activation influence treatment tolerance
• Why mold exposure, heavy metals, and environmental chemicals can prevent Lyme recovery if left unaddressed
• How environmental toxicity contributes to immune dysfunction and microbial persistence
• Strategic antimicrobial approaches using layered botanical protocols rather than aggressive eradication strategies
• The role of biofilm disruption and how to support elimination safely
• When pulsing antimicrobial therapies may be more appropriate than continuous treatment
• The potential role of immune-signaling therapies such as homeopathic nosodes in sensitive or treatment-intolerant patients
• Why antibiotics alone often fail to resolve chronic Lyme—particularly when mitochondrial dysfunction, dysbiosis, mast cell activation, and immune imbalance remain unaddressed
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By this stage of the program, practitioners understand that chronic Lyme is not simply a persistent infection—it is a state of systemic destabilization affecting nearly every major physiological system in the body.
Persistent infection, toxic burden, immune dysregulation, mitochondrial dysfunction, and nervous system hyperactivation create a feedback loop that can keep patients trapped in chronic illness even when microbial load is reduced.
In this module, we explore the broader physiological consequences of chronic Lyme and how these systems interact. Understanding these patterns helps practitioners move beyond symptom management and toward restoring true biological resilience.
You’ll learn how Lyme disrupts immune signaling, neurological regulation, hormonal balance, mitochondrial energy production, digestive health, and detoxification pathways—and why addressing these systems is essential for sustainable recovery.
You’ll learn:
How chronic Lyme alters immune signaling and regulatory balance, including cytokine shifts and impaired immune tolerance
• The role of Th1/Th2 imbalance, T-regulatory dysfunction, and mast cell activation in chronic inflammatory states
• How infection can trigger autoimmune mimicry, contributing to conditions such as autoimmune thyroid disease or inflammatory arthritis
• The neurological impact of Lyme, including neuroinflammation, limbic system activation, dysautonomia, and POTS
• Why many Lyme patients develop psychiatric and cognitive symptoms as a result of inflammatory signaling in the brain
• How chronic infection disrupts the endocrine system, including thyroid function, HPA axis regulation, and sex hormone balance
• The role of mitochondrial dysfunction, oxidative stress, and nitric oxide imbalance in fatigue, pain, and exercise intolerance
• How Lyme affects the gastrointestinal system, contributing to dysbiosis, intestinal permeability, histamine intolerance, and bile dysfunction
• The impact of chronic infection on detoxification pathways, including glutathione depletion, sulfation issues, and lymphatic stagnation
• How to recognize when treatment pacing needs to slow down to prevent nervous system crashes, mast cell flares, or severe Herxheimer reactions
• When to pivot clinical strategy if patients plateau or symptoms worsen
• Why long-term recovery requires immune recalibration, mitochondrial repair, and nervous system stabilization—not just antimicrobial pressure
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In addition to the core training modules, we’ll be spending four weeks applying these frameworks to real clinical scenarios through live case study sessions.
These sessions are designed to help you move beyond theory and develop the clinical decision-making skills needed to confidently work with complex Lyme cases. Together, we’ll walk through case examples, analyze symptom patterns, discuss testing interpretation, and explore how to sequence treatment strategies in real-world practice.
You’ll have the opportunity to see how the concepts from the course translate into clinical reasoning, including how to identify co-infections, recognize system destabilization, and adjust treatment pacing when patients are sensitive or highly reactive.
Live Case Study Call Schedule
All sessions will be held Mondays from 10:00 AM – 12:00 PM Mountain Time• May 18
• May 25
• June 1
• June 8Each session will run for two hours and will include case walkthroughs, clinical discussion, and time for practitioner questions.
If you’re unable to attend live, all calls will be recorded and available inside the course portal.
biotoxins: the missing piece
For many clients, chronic infection isn’t an obvious diagnosis—it’s the underlying pattern that has been overlooked.
Practitioners often focus on gut health, hormones, detoxification, or immune dysfunction. But when symptoms remain unexplained or resistant to treatment, it’s worth asking a different question:
What if an underlying infectious process is driving the pattern?
Lyme disease and associated co-infections rarely present as a single clear symptom. Instead, they appear as multi-system symptom clusters that evolve over time—often affecting the nervous system, immune system, endocrine signaling, and mitochondrial energy production simultaneously.
When these patterns are missed, clients may spend years cycling through treatments that only address the downstream consequences rather than the underlying driver.
Below are some of the symptom patterns frequently seen in Lyme and co-infection cases—many of which appear throughout the Horowitz MSIDS questionnaire used to screen for chronic vector-borne illness.
Neurological & Cognitive Symptoms
Brain fog, poor concentration, or slowed thinking
Word-finding difficulty or memory lapses
Head pressure or chronic headaches
Dizziness, vertigo, or balance issues
Sensitivity to light or sound
Tingling, numbness, or nerve pain
Tremors, muscle twitching, or neuropathy
These symptoms often reflect neuroinflammation and nervous system involvement, which is common in chronic Lyme.
Psychiatric or Mood Changes
Anxiety, panic attacks, or unexplained fear
Depression or emotional volatility
Sudden personality changes
Irritability, rage episodes, or intrusive thoughts
Derealization or feeling “disconnected” from reality
Sleep disruption or insomnia
Inflammatory signaling in the brain can create symptoms that appear psychiatric but are driven by infection and immune dysregulation.
Migratory Pain & Musculoskeletal Symptoms
Migrating joint pain that shifts from one area to another
Neck stiffness or TMJ pain
Rib pain or chest wall discomfort
Plantar foot pain, especially in the morning
Muscle aches, weakness, or twitching
Migratory pain patterns are one of the classic clinical clues for Borrelia infection.
Autonomic & Cardiovascular Symptoms
Heart palpitations or irregular heartbeat
Tachycardia or POTS symptoms
Air hunger or difficulty getting a deep breath
Temperature dysregulation or cold extremities
Lightheadedness when standing
These symptoms often reflect autonomic nervous system disruption, which is common in chronic infection.
Immune & Inflammatory Symptoms
Chronic fatigue or post-exertional crashes
Persistent swollen lymph nodes
Mast cell activation or histamine intolerance
New autoimmune diagnoses (Hashimoto’s, inflammatory arthritis)
Cycles of symptom flares followed by temporary improvement
These patterns often reflect immune dysregulation driven by persistent infection.
Gastrointestinal & Histamine Symptoms
Bloating, constipation, or IBS-like symptoms
Food sensitivities that continue to increase
Histamine reactions, flushing, or skin rashes
Nausea, reflux, or poor digestion
Chemical sensitivities or supplement intolerance
Chronic infection frequently disrupts gut immunity and microbial balance.
Hormonal & Metabolic Disruptions
Thyroid dysfunction or fluctuating thyroid labs
Adrenal fatigue or flattened cortisol rhythm
Menstrual irregularities or fertility challenges
Blood sugar instability
Unexplained weight changes
Chronic inflammatory signaling can significantly disrupt endocrine regulation.
When multiple systems are involved at once, the question becomes less about which single diagnosis fits and more about what underlying process could connect them.
For many complex clients, that missing piece may be Lyme disease and associated co-infections.
Understanding how to recognize these symptom patterns (and when infection should enter the differential) is a critical skill for practitioners working with chronic illness.
all the details
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The Lyme Mastery Method certification course is $1497
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This is more than just a course—it’s an immersive clinical training designed to help practitioners confidently recognize and navigate complex Lyme and co-infection cases.
Inside the Lyme Mastery Method, you’ll gain the frameworks, tools, and clinical insight needed to understand infection-driven illness and apply this knowledge in real-world practice.
Here’s what’s included:
Weekly Live Case Study Sessions with Deidre
Join us for four live case study calls where we’ll walk through real clinical scenarios and apply the frameworks from the course.
Together we’ll analyze symptom patterns, discuss testing interpretation, explore co-infection clues, and examine treatment sequencing decisions. These sessions are designed to help you translate theory into practical clinical reasoning.
Bring your questions—we’ll walk through the clinical thinking process together.
Practitioner-Ready Clinical Resources & Tools
You’ll receive practitioner-focused resources designed to support implementation in your practice, including clinical reference guides, symptom pattern tools, and educational materials you can use with clients.
These resources help you organize complex information and communicate Lyme-related concepts more clearly with patients.
Practitioner Resource Library
You’ll gain access to a curated collection of clinical materials to support your learning and application, including reference guides on Lyme biology, co-infections, testing interpretation, symptom clusters, and treatment sequencing.
This library is designed to serve as an ongoing resource as you begin integrating these concepts into your clinical work.
Private Practitioner Community for Collaboration
Inside the program, you’ll join a private practitioner community where students can connect, share insights, and discuss clinical questions.
This space allows practitioners to continue learning from each other, share case observations, and deepen their understanding of infection-driven illness patterns.
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We get started on May 18th for our next cohort.
Live case study session times are as follows:
Week 1: Monday May 18th 9-11am PT/ 10am-12pm MT/ 1-3pm ET
Week 2: Monday May 25th 9-11am PT/ 10am-12pm MT/ 1-3pm ET
Week 3: Monday June 1st 9-11am PT/ 10am-12pm MT/ 1-3pm ET
Week 4: Monday June 8th 9-11am PT/ 10am-12pm MT/ 1-3pm ET
Please note that all calls are recorded and available next day for replay access. -
For Practitioners Only
This advanced training is designed specifically for health professionals working with complex chronic illness. Participants should have a background in clinical nutrition, functional medicine, or a related field. Proof of credentials may be requested upon registration.
This program is ideal for:
NTPs, FNTPs, CNSs, nutritionists, and health coaches with clinical training
Practitioners who suspect infection may be part of the picture but want a clearer clinical framework for recognizing and addressing it
Prior Training in Toxin Mastery Method Is Strongly Recommended
Because chronic Lyme rarely exists in isolation, toxic burden and environmental exposures often play a major role in treatment resistance and recovery.
While we will discuss the role of toxins throughout this training, this course does not fully cover detoxification strategies, toxin testing, or environmental illness in depth.
For that reason, this program is best suited for practitioners who have already completed the Toxin Mastery Method, or who already have a strong foundational understanding of toxin-related illness.
